A trial in Great Brtain found the device could reduce the frequency and severity of migraines, but not prevent them, as investors had hoped. StarFlex is approved for treating a congenital heart defect called patent foramen ovale, or PFO, in which a flap of tissue is pushed open when a patient is under stress. The British study shows that there is probably a link between PFO and migraines. What exactly it is, and to what extent StarFlex can help, will be the subject of future studies.