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Cleveland Clinic's Top 10 Medical Innovations For 2020

Cleveland Clinic unveils the top 10 medical innovations for 2020.

  • Cleveland Clinic has selected the Top 10 Medical Innovations for 2020 at a multimedia presentation that capped off the 2019 Medical Innovation Summit. Now in its 17th year, the annual Medical Innovation Summit is organized by Cleveland Clinic Innovations, the development and commercialization arm of Cleveland Clinic.  What is top on the list? Counting down from 10, the clinic presents the latest in innovations. 

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  • 10. Drugs for Heart Failure with Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFpEF) – also known as diastolic heart failure – is the condition in which the ventricular heart muscles contract normally, but do not relax as they should. With preserved ejection fraction, the heart is unable to properly fill with blood – leaving less available to be pumped out to the body. Currently, recommendations for this treatment are directed at accompanying conditions and mere symptom relief. But SGLT2 inhibitors, a class of medications used in the treatment of type 2 diabetes, is now being explored in HFpEF – alluding to a potential new treatment option.

     

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  • 9. PARP Inhibitors for Maintenance Therapy in Ovarian Cancer

    PARP, or poly-ADP ribose polymerase, inhibitors block repair of damaged DNA in tumor cells which increases cell death, especially in tumors with deficient repair mechanisms. One of the most recent important advances in ovarian cancer treatment, PARP inhibitors have improved progression-free survival and are now being approved for first-line maintenance therapy in advanced-stage disease. Several additional large-scale trials are underway with PARP inhibitors set to make great strides in improving outcomes in cancer therapy.

     

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  • 8. Bempedoic Acid for Cholesterol Lowering in Statin Intolerant Patients

    High cholesterol is a major concern for nearly 40%  of adults in the U.S. Left untreated, the condition could lead to serious health problems like heart attack and stroke. Though typically managed with statins, some individuals experience unacceptable muscle pain with statins. Bempedoic acid provides an alternative approach to lowering of LDL-cholesterol while avoiding these side effects.

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  • 7. Antibiotic Envelope for Cardiac Implantable Device Infection Prevention

    Worldwide, roughly 1.5 million patients receive an implantable cardiac electronic device every year. In these patients, infection remains a major, potentially life-threatening complication. Antibiotic-embedded envelopes are now made to encase these cardiac devices, effectively preventing infection.

     

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  • 6. Biologics in Orthopedic Repair

    After orthopedic surgery, the body can take anywhere from months to years to recover. But biologics – cells, blood components, growth factors, and other natural substances – have the power to replace or harness the body’s own power and promote healing. These elements are finding their way into orthopedic care, allowing for the possibility of expedited improved outcomes.

     

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  • 5. Closed-Loop Spinal Cord Stimulation

    Chronic pain is a terribly frustrating condition and a large reason for the prescription of opioid medication. Spinal cord stimulation is a popular treatment for chronic pain through which an implantable device provides an electrical stimulus to the spinal cord. But unsatisfactory outcomes due to subtherapeutic or overstimulation events are common. Closed-loop stimulation is allowing for better communication between the device and the spinal cord providing more optimal stimulation and relief of pain.

     

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  • 4. Therapy for Mitigation of Peanut Allergies

    It’s a terrifying reality for 2.5% of parents – the possibility that at any moment, their child might be unable to breathe due to an allergic reaction. Though emergency epinephrine has reduced the severity and risk of accidental exposure, these innovations are not enough to quell the ever-present anxiety. But the development of a new oral immunotherapy medication to gradually build a tolerance to peanut exposure holds the opportunity to lend protection against attack.

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  • 3. Inaugural Medication for Transthyretin Amyloid Cardiomyopathy

    A disheartening cardiovascular disorder,ATTR-CM is a progressive, underdiagnosed, potentially fatal disease in which amyloid protein fibrils deposit in, and stiffen, the walls of the heart’s left ventricle. But a new agent to prevent misfolding of the deposited protein is showing a significantly reduced risk of death. Following Fast-Track and Breakthrough designations in 2017 and 2018, 2019 marked the FDA approval of tafamidis, the first-ever medication for the treatment of this increasingly recognized condition.

     

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  • 2. Expanded Use of Minimally Invasive Mitral Valve Surgery

    The mitral valve allows blood flow from the heart’s left atrium to the left ventricle. But in about 1 in 10 individuals over the age of 75, the mitral valve is defective causing the action of regurgitation. Expanding the approval of a minimally invasive valve repair device to a population of patients who have failed to get symptom relief from other therapies provides an important new treatment option.

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  • 1. Dual-Acting Osteoporosis Drug

    Osteoporosis is a condition in which bones become weak and brittle, effectively increasing their risk of breaking. With osteoporosis, the loss of bone occurs silently and progressively – often without symptoms until the first fracture. Providing more bone-strengthening power, the recent FDA approval of a new dual-acting drug (romosozumab) is giving patients with osteoporosis more control in preventing additional fractures.

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