William and Gayle Cook founded Cook Group Inc. in 1963. Their son Carl became the company’s chief executive officer in 2011 upon his father’s death; Gayle sits on the company's board of directors. Cook Medical, based in Bloomington, IN, sells a large range of medical products, including endovascular stent grafts for abdominal aortic aneurysms, bioengineered tissue grafts, OB/GYN products, and antimicrobial catheters.

Cook Group includes a number of other non-medical subsidiaries. The private company had approximately $2 billion in revenue in 2010.